Evidence-based. Guideline-oriented. Outside the standard physician budget.
S3 guideline-compliant CBT in an interactive, virtual dialogue
deprexis is permanently listed as a Digital Health Application (DiGA). The costs are fully covered – with no impact on your physician budget.
Simply prescribe via PZN 17265872 on "Muster 16" (standard German prescription form) or as an e-prescription.
100% outside the standard physician budget: Does not impact your pharmaceutical or therapeutic product budget.
Issuing a prescription or a confirmation of diagnosis is sufficient.
Cost coverage by most private health insurers via reimbursement.
Direct start via the website / email is possible.
Rapid help for €297.50 incl. VAT (Duration of use: 90 days).
To speed up the process for your private patients, we provide pre-formulated templates for cost estimates and confirmation of diagnosis.
Through virtual dialogues, deprexis guides patients through core CBT modules – e.g., behavioral activation, cognitive restructuring, problem-solving, managing rumination, or self-esteem.
The program actively asks questions, reacts to responses, and thus establishes individualized focus areas. In this way, deprexis imparts knowledge, encourages positive thinking patterns, and supports the development of new behavioral patterns.
On the page "How does deprexis work?" you can learn more about its structure and mechanism of action.
Worksheets and audio tracks support you in bringing more activity and structure back into your daily routine.
You can regularly log your activities and symptoms using questionnaires.
deprexis customizes itself individually to your answers and needs.
Optional email and SMS reminders motivate you to stay on track.
With the digital therapy deprexis, every patient receives optimal support right from the start. The program can be used as a standalone intervention or alongside psychotherapy and routine medical care.
deprexis specifically addresses symptom-oriented content (e.g., behavioral activation, cognitive techniques, relapse prevention) without requiring you to schedule additional consultation hours.
This provides significant relief, particularly during waiting periods and times of high demand for care: patients can immediately begin an evidence-based treatment that is effective on its own and can also enhance the outcomes of an ongoing therapy.
By prescribing deprexis, you as a healthcare provider deliver low-threshold, sustainable emergency support without impacting your own practice budget.
Uncomplicated and relieving for your practice – transparent in billing.
Below you will find key results, study designs, and context regarding patient care.
Learn more about the paths to prescription and let us guide you through the process of prescribing deprexis.
"We at DigaDocs consider deprexis to be a truly excellent DiGA that is highly versatile. It quickly gives the impression of actually engaging in a therapeutic conversation. The topics addressed provide great preparatory work for subsequent psychotherapy, or they can reinforce and deepen the content of your ongoing psychotherapy."
“Digital therapy applications such as deprexis can be a valuable supplement to medical and psychotherapeutic treatment, especially when patients need additional support between appointments or while waiting.”
Here you can find frequently asked questions about deprexis and their answers.
Worldwide, more than 275,000 affected individuals have already used deprexis.
deprexis has been available since 2007. The program has been continuously developed since then and has been used as a digital therapy for depression for over 15 years.
deprexis is a therapeutic program that has been proven in practice for over 15 years. Its efficacy has been demonstrated in a total of 16 clinical trials, making deprexis one of the most thoroughly and extensively researched digital therapies worldwide.
deprexis was developed by GAIA AG. Backing the program is an experienced, interdisciplinary team of physicians, psychologists, and psychotherapists who designed the content in collaboration with affected individuals. Furthermore, deprexis has been peer-reviewed by internationally renowned experts, among others.
Yes, when deprexis is used in addition to traditional psychotherapy, the treatment outcomes can significantly improve.
Studies show that individuals who used deprexis alongside their therapy experienced more than twice the improvement in their depressive symptoms compared to those who received traditional psychotherapy without deprexis.
Berger T, Krieger T, Sude K, Meyer B, Maercker A. Evaluating an e-mental health program („deprexis“) as adjunctive treatment tool in psychotherapy for depression: Results of a pragmatic randomized controlled trial. J Affect Disord. 2018;227:455‐462.
As a DiGA (digital health application), deprexis is listed in the BfArM directory and classified as a Risk Class I medical device (under the MDR).
Click here to learn more about the contraindications.
As with depression treatments in general, immediate medical or psychotherapeutic care is required in the event of suicidal risk or an acute crisis.
deprexis is a comprehensive, interactive therapy program that offers a wide variety of exercises and content for individuals affected by depression. Here is an overview for you:
Behavioral activation
Cognitive restructuring
Relaxation, physical activity, and lifestyle changes
Acceptance and mindfulness
Problem-solving
Childhood experiences
Interpersonal skills
Positive psychology
Dreamwork (optional)
Summary of key principles and techniques
Generally, no: deprexis is designed to be highly accessible (low-threshold), requires minimal technical setups, and is intuitive for patients to use. Experience shows that both younger and older patients cope well with the program.
If questions do arise, they usually concern the access path or the activation code. In these cases, patients can contact the deprexis technical support team directly.
No. deprexis does not refer patients to psychotherapists or physicians.
If additional support is needed, a medical or psychotherapeutic practice can be contacted directly. The medical appointment service (Terminservicestelle) at 116 117 can also assist in finding a suitable treatment option.
deprexis can be prescribed by all physicians and psychotherapists – regardless of the specific form of therapy they offer (e.g., psychodynamic or cognitive behavioral).