What is deprexis?

What is deprexis?

Support for your mental well-being, always within reach

deprexis is an evidence-based digital program designed to complement care for adults experiencing depressive symptoms – providing structured support for mild, moderate, and severe symptoms alike.

deprexis offers an interactive experience that adapts to your individual responses, guiding you through proven strategies to help manage your condition. Over time, it helps you build healthy daily routines and enhance your overall emotional well-being.

Designed as an adjunct to your standard care routine, deprexis lets you learn, reflect, and practice at your own pace – whenever and wherever you feel most comfortable.

Instantly
available

Easy online
access

Individually
tailored

Clinically
studied

What makes deprexis stand out?

Over 275,000
people worldwide

have already used deprexis for mental health support.

15+ years of clinical experience

demonstrating long-term utility and user engagement in real-world application.

Extensively researched

evaluated across 16 clinical trials with over 2,800 participants worldwide.

83% of users


would recommend deprexis to a friend or loved one.

Get started with deprexis

What is a Digital Therapeutic (DTx)?

Digital Therapeutics (DTx) are evidence-based digital health applications that you can conveniently access on your smartphone, tablet, or computer. Designed to support you in managing specific health conditions, a DTx serves as a valuable complement to your ongoing medical or psychological care.

Safety, quality, and data privacy are top priorities. As a regulated digital health application, deprexis is built to meet strict regulatory and data protection standards and in Europe, it holds a full CE mark as a certified medical device!

Key takeaways at a glance:

Regulated & Secure

Digital Therapeutics (DTx) are held to high regulatory and data privacy standards to ensure safety, quality, and data security.



Easily Accessible


You can conveniently access deprexis online from the comfort of your home, using your smartphone, tablet, or computer whenever you need it.


Designed as an Adjunctive Tool

deprexis is built to complement your overall mental health journey and can be seamlessly used alongside your standard daily care or existing treatment.

Daily Support & Empowerment

deprexis empowers you to take an active role in managing your emotional well-being through interactive exercises, CBT-based tools, and self-monitoring.

How deprexis works – Understanding thoughts, emotions, and behaviors

deprexis is based on Cognitive Behavioral Therapy (CBT) — a clinically studied and established approach for supporting mental well-being. When it comes to managing depression, CBT-based strategies are highly recommended and form a core component for addressing depressive symptoms.

How does Cognitive Behavioral Therapy work?

Our thoughts influence how we feel, act, and perceive our daily lives. In the case of depression, this can easily turn into a distressing cycle.

Cognitive Behavioral Therapy addresses this exact connection, unpacking how our thoughts, feelings, and actions intertwine. It empowers us to question negative thought patterns and discover new perspectives, paving the way for lasting behavioral change.

Modern approaches to CBT – such as the ones utilized by deprexis – go a step further. It is not about labeling thoughts as "right" or "wrong" or forcing yourself to change them. Thoughts are allowed to be there. Even the difficult ones.

Instead of fighting distressing thoughts, you learn to develop a new way of relating to them, to notice them, gain some distance, and align yourself with what truly matters to you. The goal is not positive thinking at all costs, but a compassionate relationship with yourself. Enabling you to stay empowered and take action, even when difficult thoughts arise.

How does deprexis support you in this process?

deprexis translates the core principles of CBT into an interactive digital program that meets you exactly where your thoughts arise: right in the middle of your daily life.

Through tailored dialogues and a wide range of practical exercises, deprexis offers actionable insights and tools to help you:

  • recognize unhelpful thought patterns
  • pause and gain perspective
  • better understand and manage your emotions
  • develop effective daily coping strategies

A look inside the program:
compassionate, structured, made for daily life

Built on evidence-based Cognitive Behavioral Therapy (CBT) principles, deprexis is a clinically studied digital program designed to support and complement your ongoing care.

Through up to 10 sequential, interactive virtual sessions, the program gently guides you through tailored insights and practical exercises designed to fit seamlessly into your daily routine.

Getting Started & Introduction

Behavioral activation

Cognitive Restructuring

Relaxation & Lifestyle

Acceptance & Mindfulness

Reflecting on Early Experiences

Interpersonal Communication

Positive Psychology

Dream Work


Problem-Solving Skills

What else you’ll find in deprexis:

Exercises

deprexis includes numerous worksheets and audio tracks designed to help boost your mood and energy levels.

Progress

Easily log your activities and symptoms through regular questionnaires, making it simpler to track how your daily routine connects to your mood.

Dialogue

deprexis adapts to your answers and personal focus areas, ensuring you get content that truly matters to you – not a one-size-fits-all solution.

Reminders

Optional email and SMS reminders provide quick recaps of what you’ve learned, keeping you motivated and on track.

Accessible
anywhere

Wherever you are – at home, on the go, or during your lunch break. Use it easily on your computer, tablet, or smartphone.

Tailored to your needs

We recommend 1–2 sessions per week, taking about half an hour each.


For 90
days

From your first login, you can use deprexis for 90 days. With every follow-up subscription, you get another 90 days of access.

Go at your
own pace

Take breaks whenever you need and jump back in anytime with zero pressure. There are no fixed appointments.

deprexis is right for you if you want to…

… find support while experiencing depressive symptoms.

… actively break free from the cycle of depression.

… access adjunctive care whenever and wherever it suits you.

… effectively complement your ongoing treatment or therapy.

deprexis is not a substitute for acute crisis intervention.

In the case of acute suicidal ideation or psychiatric emergencies, it is critical that you reach out immediately to a doctor, therapist, or emergency services.

Wondering who developed deprexis?

deprexis was built by a dedicated team of medical doctors, psychotherapists, and scientists. For over 15 years, it has been actively used as an adjunct in the treatment of depression, and with 16 clinical trials, it stands as the most thoroughly researched digital therapy worldwide. Developed alongside leading experts and renowned researchers, deprexis has been comprehensively evaluated to ensure the highest standards of adjunctive care.

What the experts say

Foto von Dr. Gitta Jacob im Halbprofil

“Depression is a serious condition – but it is also highly treatable, and many of those affected benefit greatly from the right support.

That is why deprexis is so valuable. It offers a modern, evidence-based approach that is instantly available, completely bypassing long waiting lists. It empowers you to break free from negative thought patterns and helps you rediscover the brighter sides of life.”

Dr. Gitta Jacob
Head of Research & Development

What do the studies show?

The effectiveness of deprexis has been extensively researched across mild to severe depressive symptoms. The program delivers clinically demonstrated benefits as an adjunctive tool — whether used alongside standard care, outpatient treatment, or ongoing psychotherapy.
50 %+
of users reported a clinically significant improvement in their depressive symptoms.1
83 %
would recommend deprexis to a friend or family member dealing with depression.1
70 %
noticed a positive therapeutic impact after just 3 weeks.1



200 %+
greater reduction in depressive symptoms when deprexis was used alongside regular psychotherapy.2
1 Meyer B, Bierbrodt J, et al. Effects of an Internet Intervention (Deprexis) on Severe Depression Symptoms: Randomized Controlled Trial. Internet Interventions. 2015;2(1):48–59. https://www.sciencedirect.com/science/article/pii/S2214782914000402?via%3Dihub

2 Berger T, Krieger T, Sude K, Meyer B, Maercker A. Evaluating an e-mental health program (“deprexis”) as an adjunctive treatment tool in psychotherapy for depression: Results of a pragmatic randomized controlled trial. J Affect Disord. 2018;227:455–462.


Depression feels different for everyone—yet so many share the very same thoughts.

deprexis is right there with you in those moments.

User Journeys

Lachende Frau mit kurzen, schwarzen Haaren in grüner Jacke
I was immediately impressed by deprexis. The program adapts to my personal needs and takes the time to get to know me first. The bird’s-eye view exercise was especially helpful.
Miriam
63
Lächelnde blonde Frau steht auf einer Straße mit grünem Schal und schwarzer Jacke
Using deprexis was a sign for me that I was actually taking action. I knew it would help me, and it’s always better to do just a little something than to do nothing at all.

Thea
31
Lachender Mann in pinkem Hemd sitzt auf einem Bürostuhl
deprexis taught me to think outside the box. Not always sticking to the same old routines – like taking a different route for a walk than usual, or calling someone the moment they cross my mind.
Georg
55

Starting something new isn’t always easy—and it’s completely okay to ask for support.

Making decisions about your own health can feel overwhelming at times. The following guidance is designed to help you gain clarity, navigate any uncertainties, and figure out what feels right for you.