deprexis has been evaluated in rigorous clinical trials conducted in collaboration with leading academic institutions and clinical centers worldwide.

In the United States, research was conducted in partnership with the University of Texas at Austin (1).

International and European research partners include:

• University of Lübeck / UKSH
• University Medical Center Hamburg-Eppendorf (UKE)
• Charité – Universitätsmedizin Berlin
• University of Bern
• Bielefeld University
• University of Trier
• University of Tübingen

References:

1. (1) Beevers CG, Pearson R, Hoffman JS, et al. Effectiveness of an internet intervention (Deprexis) for depression in a united states adult sample: A parallel-group pragmatic randomized controlled trial. J Consult Clin Psychol. 2017;85(4):367-380.
2. (2) Meyer B, Bierbrodt J, Schröder J, et al. Effects of an Internet Intervention (Deprexis) on Severe Depression Symptoms: Randomized Controlled Trial. Internet Interventions. 2015;2(1):48–59.
3. (3) Berger T, Krieger T, Sude K, et al. Evaluating an e-mental health program ("deprexis") as adjunctive treatment tool in psychotherapy for depression: Results of a pragmatic randomized controlled trial. J Affect Disord. 2018;227:455–462.

A comprehensive list of clinical research projects, peer-reviewed publications, and study results can be found on the GAIA website in the Research section. Key clinical trials, including the large-scale EVIDENT study, and details on academic research partnerships are highlighted there and updated regularly.

In scientific and medical literature, deprexis is widely recognized as one of the most thoroughly evaluated digital Cognitive Behavioral Therapy (CBT) programs available.

Recent reviews highlight deprexis as an application backed by one of the most extensive bodies of clinical evidence in the digital health space. Meta-analyses consistently confirm its efficacy, drawing on data from 12 randomized controlled trials (RCTs) involving nearly 3,000 patients (n=2,901).

Furthermore, independent medical evaluations confirm the program's strong evidence base, noting that its adaptive dialogue structure and therapeutic functions are exceptionally suited for helping individuals manage depressive symptoms effectively.

Yes. deprexis is specifically designed as an adjunctive digital program to be used alongside your ongoing care, such as traditional psychotherapy or psychiatric treatment. It is not intended as a standalone therapy or replacement for professional treatment.

When used as an adjunctive tool, deprexis can significantly enhance overall care outcomes. Clinical research shows that individuals who used deprexis alongside their standard therapy experienced more than double the improvement in their depressive symptoms compared to those receiving traditional psychotherapy alone.

Reference:

(1) Berger T, Krieger T, Sude K, Meyer B, Maercker A. Evaluating an e-mental health program ("deprexis") as adjunctive treatment tool in psychotherapy for depression: Results of a pragmatic randomized controlled trial. J Affect Disord. 2018;227:455–462.

For healthcare providers, it is important to know that deprexis is not a static, one-size-fits-all program. It utilizes an advanced, dialogue-based system that dynamically adapts its content based on each user's specific symptoms, goals, and ongoing progress.

Through tailored choice pathways and continuous feedback, users can set their own focus areas and progress at their own pace. This responsive design ensures that the program delivers highly relevant, practical support for individuals as an adjunctive resource alongside your clinical care.

For healthcare providers, pacing and user engagement are key considerations. deprexis is intentionally designed to foster self-efficacy while preventing burnout. Users explore CBT-based content at their own comfortable pace, practicing real-world strategies and receiving structured, actionable feedback that makes their progress tangible.

To maintain a balanced and sustainable routine, the program generally encourages users to engage once or twice a week for about 30 to 60 minutes. Because the dynamic dialogue adapts to user inputs, individuals can pause, resume, or revisit modules whenever they need to, ensuring the experience remains supportive rather than overwhelming.