Deliver Evidence-Based Adjunctive Relief for Depressive Symptoms — deprexis.

Evidence-Based. Accessible Anywhere.

  • CBT-Based Interactive DialoguesDelivers structured Cognitive Behavioral Therapy (CBT) principles in an adjunctive strategy, interactive, personalized virtual format, aligned with clinical practice guidelines.
  • Extensively StudiedClinical benefits supported by 11 randomized controlled trials (RCTs) involving over 2,800 participants
  • Broad ApplicabilityDesigned to support individuals across mild to severe depressive symptoms.
  • Suitable for Diverse Age GroupsEvaluated for adults across all age groups, including older adults (18+ and 65+).
  • Seamless Digital AccessAn easy-to-integrate adjunctive tool designed to complement standard clinical care without extra administrative burden.

ICD-10:

  • F32.0 / F32.1 / F32.2 depressive episode
  • F33.0 / F33.1 / F33.2 recurrent depressive disorder

ICD-11:

  • 6A70 Single episode depressive disorder
  • 6A71 Recurrent depressive disorder

Contraindications

  • F20 Schizophrenia
  • R45.8 Other symptoms involving mood (e.g., acute suicidality)
  • F23 Acute and transient psychotic disorders
  • F31 Bipolar affective disorders
  • F25 Schizoaffective disorders

deprexis: An Interactive, Adjunctive CBT Approach in a Conversational Style

Through structured virtual dialogues, deprexis guides patients through core evidence-based CBT modules — including behavioral activation, cognitive restructuring, problem-solving, rumination management, and self-esteem enhancement.

The software dynamically adapts to patient inputs to deliver an individualized experience. In doing so, deprexis reinforces therapeutic concepts, fosters constructive cognitive patterns, and supports behavioral change in everyday life.

Exercises

Worksheets and audio tracks support you in bringing more activity and structure back into your daily routine.

Progress

You can regularly log your activities and symptoms using questionnaires.


Dialogues

deprexis customizes itself individually to your answers and needs.


Screenshot mit Einblick in deprexis

Reminders

Optional email and SMS reminders motivate you to stay on track.


Explore deprexis

The Benefits of deprexis

With deprexis, patients receive evidence-based digital support right from the start. Designed as an adjunctive tool, the program seamlessly complements routine medical care or ongoing psychotherapy.

deprexis specifically addresses symptom-oriented CBT content (e.g., behavioral activation, cognitive techniques, relapse prevention), so patients can immediately engage with an evidence-based tool that provides continuous between-session care and helps enhance overall outcomes alongside their treatment plan.

16 Studies,
15 Years in Clinical Practice,
Proven Effectiveness

  • Scientific evidence:
    Significant reduction of symptoms proven in 16 RCTs and meta-analyses.
  • Maximum flexibility:
    Effective across all levels of severity – as a standalone intervention or to enhance the success of ongoing treatment.
View study details

Experiences from Healthcare Providers

Mann mit Bart und Brille lächelt in die Kamera

"We at DigaDocs consider deprexis to be a truly excellent DiGA that is highly versatile. It quickly gives the impression of actually engaging in a therapeutic conversation. The topics addressed provide great preparatory work for subsequent psychotherapy, or they can reinforce and deepen the content of your ongoing psychotherapy."

Dr. med. Lars Lomberg

Any questions?

Here you can find frequently asked questions about deprexis and their answers.