deprexis — One of the Most Clinically Studied Tools for Adjunctive Care Worldwide

deprexis Clinical Studies: Key Data at a Glance

With 16 randomized controlled trials, deprexis is one of the most extensively researched adjunctive digital CBT tools for depressive symptoms.






Current meta-analysis based on 12 RCTs (total N = 2,901) involving participants with varying severities of depressive symptoms¹







For all severities of depressive symptoms, even in severe cases: In a study on the use of deprexis for severe depressive symptoms, adults with initially severe symptoms (PHQ-9 ≥ 15) were randomized (N = 163). Among other findings, a between-group effect size of d = 0.57 after 3 months was reported.

Convincing in adjunctive care: In the EVIDENT RCT (N = 1,013), deprexis was evaluated as a 12-week internet intervention added to treatment as usual (TAU) and achieved a clinically relevant, greater reduction of mild to moderate depressive symptoms (PHQ-9 5–14) compared to TAU alone.

Consequently, the evidence base for deprexis is not only quantitatively robust due to the large number of studies, but also methodically sound, characterized by a high proportion of RCTs, large sample sizes, and meta-analyses. Furthermore, various treatment settings were included, alongside routine medical care, inpatient or outpatient psychotherapy.²,³


1 Twomey, C., O’Reilly, G., Byrne, M., Bury, M., White, A., Kissane, S., & McMahon, A. (2020). Effectiveness of a tailored, integrative Internet intervention (deprexis) for depression: Updated meta-analysis. PLOS ONE, 15(1), e0228100.

2 Meyer, B, Bierbrodt, J, et al. Effects of an Internet Intervention (Deprexis) on Severe Depression Symptoms: Randomized Controlled Trial. Internet Interventions. 2015; 2(1):48–59. https://doi.org/10.1016/j.invent.2014.12.003

3 Berger T, Krieger T, Sude K, Meyer B, Maercker A. Evaluating an e-mental health program („deprexis“) as adjunctive treatment tool in psychotherapy for depression: Results of a pragmatic randomized controlled trial. J Affect Disord. 2018;227:455‐462.

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